The Midlife Sleep Struggle Is Real, But It’s Absolutely Treatable
- Barbara Johnson, MD
- Jul 2
- 3 min read
Updated: 2 days ago
If your nights are filled with tossing, turning, sudden wake-ups, or waking in a pool of sweat, you’re not alone—and you’re not imagining it. For many women in their 40s and early 50s, sleep starts to feel elusive. It’s a common and frustrating shift that often shows up without warning.
What’s behind it? In many cases, the culprit is perimenopause—the years leading up to menopause when estrogen and progesterone begin to fluctuate. These hormonal changes can wreak havoc on your sleep, triggering everything from nighttime anxiety and mood changes to hot flashes and frequent awakenings.
But here’s the hopeful news: You don’t have to accept restless nights as your new normal. With the right approach, deep, rejuvenating sleep is still within reach.

Perimenopause And Sleep
As estrogen and progesterone levels decline, your body’s natural systems for regulating temperature, mood, and sleep begin to shift. Lower levels of these hormones can interfere with the production of serotonin and melatonin, which are essential for maintaining a healthy sleep cycle.
At the same time, the pressures of midlife—raising teens, supporting aging parents, advancing your career—can pile up. These life stressors often amplify sleep problems by fueling nighttime worry, emotional overload, and even depression.
And as hormonal protection wanes, many women become more susceptible to underlying sleep disorders, such as insomnia, sleep apnea, or restless leg syndrome, often without realizing it.
Ways to Improve Sleep During Perimenopause
While there's no quick fix that works for everyone, the most effective strategies address what’s driving your symptoms, not just the symptoms themselves.
At The Johnson Center for Health, we take a whole-person approach to midlife transitions through our Aging Elegantly program. This includes:
Functional lab testing to assess hormone levels, nutrient deficiencies, inflammation, and stress biomarkers
Bioidentical hormone therapy customized to your body’s needs—not a one-size-fits-all dose
Personalized supplement protocols to support adrenal health, reduce nighttime cortisol, and restore circadian balance
Targeted nutrition and lifestyle coaching to help your body transition with strength, clarity, and grace
These services are designed to help you sleep better, feel more energized, and move through this life phase with confidence.
Improve your sleep hygiene
Before diving into advanced treatment options, it’s important to get the basics right. These foundational sleep hygiene practices can lay the groundwork for better rest:
Stick to a regular sleep and wake schedule—even on days off
Create a sleep-friendly space: cool, dark, and screen-free
Avoid stimulants like caffeine or alcohol close to bedtime
Aim for at least 150 minutes of weekly exercise, with a focus on strength and walking
Develop a calming nighttime routine like journaling, stretching, or reading
If you’re doing all of this and still waking up groggy or wired, it may be time to take a closer look at your hormones.
Target the Hormonal Imbalance
When sleep is interrupted by hot flashes, night sweats, or anxiety, hormone fluctuations are often to blame. In many cases, bioidentical hormone therapy (BHRT) can be a safe, effective option.
Unlike conventional hormone therapy, BHRT uses compounds that are structurally identical to the hormones your body naturally produces, and they’re prescribed based on your individual lab results and health history. With the right dosing, BHRT can:
Improve sleep quality
Reduce hot flashes and night sweats
Boost mood and cognitive clarity
Protect bone and heart health
Don't overlook your mental health
Midlife sleep issues aren’t just physical. If anxiety, stress, or mood shifts are keeping you up at night, addressing your mental health is essential for full-body healing.
Depending on your needs, support may include:
Cognitive Behavioral Therapy (CBT) for anxiety, racing thoughts, or low mood
Targeted nutrients like magnesium, GABA, adaptogenic herbs, or B-complex vitamins
In some cases, antidepressants such as SSRIs or SNRIs to help rebalance brain chemistry
At The Johnson Center, we help you determine whether poor sleep is stemming from emotional stress, hormonal changes, or dysregulated cortisol—and develop a plan that brings the nervous system back into balance.
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